Theoretical foundations and future perspectives for new evaluations and clinical interventions in individuals with copd with sarcopenia : the interaction between gerontology and pulmonology

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dataload.collectionmapped01 - Doutorado - CiĂȘncias da Reabilitaçãopt_BR
dataload.filenamenourau8880.pdfpt_BR
dataload.handlemapped123456789/79pt_BR
dataload.idpergamum85487pt_BR
dataload.idvirtuanourauvtls000236931pt_BR
dataload.idvirtuapergamumvtls000236931pt_BR
dataload.idvirtuapergamum.sameurlnourauSIMpt_BR
dataload.linknourauhttp://www.bibliotecadigital.uel.br/document/?code=vtls000236931pt_BR
dataload.linknourau.regularSIMpt_BR
dataload.linknourau.retificadohttp://www.bibliotecadigital.uel.br/document/?code=vtls000236931pt_BR
dataload.linknourau.size64.00pt_BR
dc.contributor.advisorProbst, Vanessa Suziane [Orientador]pt_BR
dc.contributor.authorLoyola, Walter Aquiles SepĂșlvedapt_BR
dc.contributor.bancaCamillo, Carlos Augusto Marçalpt_BR
dc.contributor.bancaMañas, Leocadio Rodríguezpt_BR
dc.contributor.bancaTeixeira, Denilson de Castropt_BR
dc.contributor.bancaOkamura, Larissa AraĂșjo de Castropt_BR
dc.coverage.spatialLondrinapt_BR
dc.date.accessioned2024-05-01T11:40:24Z
dc.date.available2024-05-01T11:40:24Z
dc.date.created2022.00pt_BR
dc.date.defesa03.06.2022pt_BR
dc.description.abstractother1Abstract: Introduction: The following doctoral thesis aimed to answer the main gaps in the literature related to the relationship between COPD and sarcopenia, its clinical impact and associated biological factors Additionally, we have described and defined a new geriatric syndrome and proposed a new exercise program based on functional tasks in order to prevent and treat the functional impact caused by sarcopenia and other geriatric syndromes Methods: Seven studies were included in this thesis, developed in collaboration with different international research centers In the first study the clinical impact, prevalence and criteria to diagnose sarcopenia in individuals with COPD was investigated In the second study the main biological mechanisms associated with the prevalence of sarcopenia in individuals with COPD were investigated The third and fourth studies analysed the relationship between oxidative stress and some clinical variables related to the presence of sarcopenia in individuals with COPD In the fifth study the criteria and clinical impact of a new geriatric syndrome called osteosarcopenia were presented The sixth and seventh studies proposed a new exercise intervention method to treat older adults with geriatric syndromes Results: The first study reported that overall sarcopenia prevalence varied from 15% to 34%, being greater in people with more severe condition [37% (95%CI 248–54)] In addition, the presence of sarcopenia has a negative impact upon important clinical outcomes The second study found that oxidative stress, chronic inflammation, genetic and metabolic factors are the main biological mechanism related to the presence of sarcopenia in individuals with COPD The third and fourth studies reported that the total radical trapping antioxidant parameter (TRAP) and advanced oxidation protein products (AOPP) are important biomarkers related to clinical variables associated to sarcopenia in individuals with COPD and that antioxidant capacity was correlated with muscle mass and strength in this population (r from 5 to 64) The fifth study reported that osteosarcopenia (using the severe sarcopenia classification) conferred an increased rate of falls [odds ratios (ORs) from 283 to 363; P <5 for all] and fractures (ORs from 386 to 438; P < 5 for all) The sixth and seventh studies found that the exercise intervention method improves the clinical variables of sarcopenia in community older adults Conclusion: Sarcopenia is highly prevalent in individuals with COPD, generating a negative impact on various clinical variables Its origin is due to the presence of various factors such as oxidative stress and systemic inflammation related to COPD Sarcopenia may also be associated with low bone mineral mass, a syndrome called osteosarcopenia, which has a greater impact than sarcopenia alone Functional physical exercise could be a great intervention to reduce the risk of sarcopenia and other geriatric syndromes Since this exercise method has been studied in community older adults, future clinical randomized control trials are needed in individuals with COPD and other comorbiditiespt_BR
dc.description.notesTese (Doutorado em CiĂȘncias da Reabilitação) - Universidade Estadual de Londrina, Centro de CiĂȘncias da SaĂșde, Programa de PĂłs-Graduação em CiĂȘncias da Reabilitaçãopt_BR
dc.identifier.urihttps://repositorio.uel.br/handle/123456789/8795
dc.languagepor
dc.relation.coursedegreeDoutoradopt_BR
dc.relation.coursenameCiĂȘncias da Reabilitaçãopt_BR
dc.relation.departamentCentro de CiĂȘncias da SaĂșdept_BR
dc.relation.ppgnamePrograma de PĂłs-Graduação em CiĂȘncias da Reabilitaçãopt_BR
dc.subjectGeriatriapt_BR
dc.subjectIdosospt_BR
dc.subjectDoençaspt_BR
dc.subjectPneumologia - Idosopt_BR
dc.subjectTratamentopt_BR
dc.subjectGeriatricspt_BR
dc.subjectElderly - Diseasespt_BR
dc.subjectPulmonology - Rehabilitation - Treatmentpt_BR
dc.titleTheoretical foundations and future perspectives for new evaluations and clinical interventions in individuals with copd with sarcopenia : the interaction between gerontology and pulmonologypt_BR
dc.typeTesept_BR

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